Pharmaceuticals used to treat testicular cancer: A variety of treatments are used to treat cancers. For the treatment of testicular cancer, the most widely used drugs are given below, along with their primary adverse effects.

  1. BLEOMYCIN

Bleomycin is a clear, colourless solution that can be combined into bigger bags of fluids. It is also known as blenoxane. It works in a cell cycle phase-specific manner.

Bleomycin is an antibiotic compound produced by the fermentation of streptomyces verticillus. The development of an intermediate iron complex causes single and double stranded DNA to break. This medication inhibits DNA synthesis, as well as RNA and protein synthesis to a lesser extent. It's commonly used to treat testicular cancer, but it can't be taken by mouth.

When used with nephrotoxic medications, caution should be exercised since bleomycin clearance may be reduced. In individuals with pre-existing renal or pulmonary problems, as well as those over the age of 70, bleomycin for testicular cancer should be administered with extreme caution.

SIDE EFFECTS

  • Arterial thromboembolism can occur at any time throughout the injection process.
  • Hypotension can happen right after an injection in some situations, but it's a rare occurrence.
  • Partial baldness, nail problem, pruritus, rashes, and skin discoloration are only a few of the dermatologic adverse effects that might occur soon after starting this medication.
  • Bleomycin causes a lot of adverse effects include fever, chills, and tumour discomfort.
  • Anorexia, combined with mild nausea and vomiting, is a typical adverse effect.
  • The reason for aberrant renal function is extremely rare, however it is a probable side effect. Mucositis, disseminated intravascular coagulation, hemolytic uremic syndrome, phlebitis, and other uncommon injection-site side effects include mucositis, disseminated intravascular coagulation, hemolytic uremic syndrome, and phlebitis.
  • Anaphylaxis is a common side effect in lymphoma patients who take this medication.


2. CARBOPLATIN

Carboplatin, also known as Paraplatin AQ, is a clear, colourless solution that is blended into bigger bags of fluids. It can be administered orally or intravenously, however the absorption is higher intravenously.

Carboplatin is thought to have no unique cell cycle phase effects, however new research has revealed that it has a complex and variable influence on the cell cycle. Carboplatin is a cisplatin derivative that acts in the same way as cisplatin. After injection, highly reactive platinum complexes form intracellularly. These complexes prevent DNA synthesis by forming intrastrand and interstrand DNA crosslinks by binding DNA molecules.

SIDE EFFECTS

  • Hearing loss of up to 15% is possible, and partial vision impairment is also possible as a result of the drug's CNS effects.
  • In the early phases of injection, arterial thromboembolism, hypertension, and venous thromboembolism may occur.
  • When carboplatin is used to treat testicular cancer, alopecia is a rare adverse effect.
  • Anorexia, constipation, diarrhoea, nausea, and vomiting are all common side effects.
  • It's possible to notice abnormal electrolyte(s) (a drop in Na, K, Ca, and Mg).
  • In the early stages, severe nephrotoxicity is possible.
  • In the later phases after injection, secondary malignancy may be visible.

3. ETOPOSIDE

Etoposide, also known as vepesid, is a clear light yellow solution that can be injected into bigger bags of fluids or given orally in pink capsules. It is effective in both forms. Etoposide, like other drugs, has a cell cycle phase specificity. It's a podophyllotoxin generated from the root of podophyllum peltatum that's semi-synthetic. Single strand breaks in DNA are known to occur as a result of it. Etoposide also damages DNA by inhibiting topoisomerase II and activating oxidation-reduction processes, resulting in compounds that bind to DNA directly. Topoisomerase II is a DNA breakage and reunion enzyme that is required for normal cellular activity.

SIDE EFFECTS

Extravasation is the inadvertent leaking or escape of a medication or solution from a vein, or the unintentional injection of a drug or solution into surrounding healthy tissue, which can induce discomfort at the injection site or along the vein, with or without an inflammatory reaction.

  • Side effects include arrhythmia, arterial thromboembolism, flushing, and hypertension.
  • One of the most common side effects of etoposide treatment for testicular cancer is alopecia. Nail discoloration or skin discoloration is a rare adverse effect that can appear weeks or months after the injection.
  • Under high dose protocol, erythematous maculopapular rash and palmar erythema are possible side effects.
  • Toxic epidermal necrolysis, also known as Stevens-Johnson syndrome, can occur in the early stages of injection.
  • Anorexia, diarrhoea, and abdominal pain are all visible symptoms.
  • Some of the less common adverse effects include constipation, mucositis, and nausea.
  • In the early stages, haematological side effects such as leukopenia (grade 4), thrombocytopenia, and others may be observed.
  • With high dose treatments, LFTs can be severe.
  • In hypersensitive individuals, drug reactions such as type 1 anaphylactoid can be detected.
  • Compensated metabolic acidosis might develop in the early or late stages of injection in high dose regimens settings.
  • In the later phases of injection, secondary leukaemia may develop, as well as a variety of nervous system diseases such as sadness, dizziness, and dysgeusia.
  • Seizures, somnolence, and cortical blindness are just a few of the negative effects that might occur.