The cancer has progressed beyond the mucosa and submucosa in this stage, and has spread beyond the mucosa and submucosa. Stage 2 is further divided into stages 2A, 2B, and 2C. Colon cancers in stage 2 have progressed to the colon wall and surrounding tissue but not to the lymph nodes.

Stage 2A

  • T3: The cancer has progressed to the outermost layers of the colon, but not through them, and is referred to as T3.
  • N0: The malignancy has not spread to the lymph nodes in the area.
  • M0: The cancer hasn't spread to other parts of the body or to other organs.

Stage 2B

  • T4a: The cancer has spread through the colon's exterior wall (serosa), but not into the surrounding tissues or organs.
  • N0: The malignancy has not affected  the lymph nodes in the area.
  • M0: The cancer hasn't spread to other parts of the body or to other organs.

Stage 2C

  • T4b: The cancer has spread through the colon's wall and has been connected to or infiltrated adjacent tissues and organs.
  • N0: The malignancy hasn't spread to the lymph nodes in the area.
  • M0: There is no evidence that the malignancy has spread to other organs or sites.
  • T1 or T2: The malignancy has spread into the submucosa after passing through the mucosa (T1). It's also possible that it grew into the muscularis propria (T2).
  • N1a, or N1c: The malignancy has expanded to 1 to 3 neighbouring lymph nodes (N1), although there are deposits in the subserosa, or tissues close to the colon (N1C).
  • M0: It has not spread to other locations.


The most common treatment for stage 2 colon cancer is surgery. A partial colectomy is performed, which involves the removal of a cancerous portion of the colon. The lymph nodes in the area are sometimes removed as well. Adjuvant chemotherapy, which is chemotherapy administered after surgery, may also be recommended by the doctor. This is something the doctor suggests for people who are at a higher risk of cancer recurrence. The likelihood of cancer recurrence is influenced by a number of factors, including:

  • When examined under a microscope, the cancer appeared to be of a high grade or atypical nature.
  • The cancer has spread to adjacent lymph nodes or blood arteries.
  • Cancer was discovered at or around the excised tissue's margins.
  • The colon had become clogged due to the malignancy.
  • The malignancy ripped a hole in the colon's wall.

Chemotherapy is a treatment that can be used in conjunction with other therapies. It's critical to explore the benefits and drawbacks of chemotherapy with your doctor, particularly how much the risk of cancer recurrence is reduced.

Stage 2 colon cancer prognosis

The relative survival percentage for persons with stage 2A colon cancer is 87 percent, while the relative survival rate for people with stage 2B colon cancer is 65 percent.