The symptoms of laryngeal cancer vary depending on where the primary tumour is located, such as the supraglottic region, glottis, or subglottic region.

A persistent change in voice is the most prevalent symptom of glottic malignancy (hoarseness of voice). Throat pain, or the sensation of a lump in the throat, is the most common sign of supraglottic carcinoma. Other symptoms include neck swelling, a "hot potato" voice, earache, and difficulty swallowing meals. Patients with advanced laryngeal cancer may experience symptoms such as unexplained weight loss and appetite loss.