Cancer that has reappeared after primary treatment is referred to as recurrent stomach cancer. The cancer in patients with resistant stomach cancer has stopped responding to primary or subsequent therapy.

Treatment is determined by a variety of considerations, such as the potential advantages of having cancer treatment versus the potential hazards of obtaining cancer treatment. A general review of the therapy of recurrent or refractory stomach cancer is provided here. Individual circumstances and cancer prognostic variables may eventually impact how these general therapy approaches are utilised.

Clinical trials are used to develop the majority of new therapies. Clinical trials are research studies that are used to determine the efficacy of new medications or treatment techniques. The benefits of enrolling in a clinical trial include easier access to improved medicines and the advancement of current understanding about cancer treatment. Most cancer stages have clinical trials available. Patients who are thinking about participating in a clinical trial should talk to their doctor about the risks and advantages. Staying informed and following cancer news to learn about new treatments and clinical trial outcomes can aid in making informed decisions.

Patients with stomach cancer who are progressing have been thought to have few therapy options, however they may benefit from extra treatment. Medical oncologists, radiation oncologists, surgeons, gastroenterologists, and nutritionists are all vital members of a multi-modality therapy team that includes medical oncologists, radiation oncologists, surgeons, gastroenterologists, and nutritionists.


Chemotherapy is the most common treatment for people who have cancer that has returned after surgery or who have had a cancer recurrence. Chemotherapy can help patients with advanced stomach cancer feel better and live longer. There are several chemotherapy regimens to choose from, and which one to employ is determined in part by the patient's condition and previous treatments. Chemotherapy can be used alone or in combination with other therapies such targeted therapy, radiation therapy, and surgery.

Targeted Treatment

Drugs that target specific pathways involved in cancer growth or dissemination are known as targeted treatments. A protein known as HER2 (human epidermal growth factor receptor 2) contributes to the growth of some stomach tumours. Herceptin®, a HER2-targeting medication, may be used to treat metastatic gastric tumours that test positive for HER2 (trastuzumab). Herceptin is frequently used in conjunction with chemotherapy to help patients with advanced, HER2-positive stomach cancer live longer.


Surgery may be performed on patients with recurrent gastric cancer to control bleeding or prevent the disease from obstructing the intestines or stomach.

Radiation Therapy

Radiation therapy is the process of killing cancer cells by using a specific sort of energy called ionising radiation. Radiation therapy can help manage the symptoms of advanced stomach cancer, as well as address issues including bleeding and obstructions.

Nutritional Assistance

To avoid difficulties, it is critical to adequately prepare the patient before to any surgical treatment. At the time of diagnosis, many patients with stomach cancer are malnourished. Although aggressive nutritional support has not been found to increase long-term survival, it has been shown to improve post-operative survival. Pre-surgery nutrition can be improved by feeding intravenously and/or through a nasogastric tube.

Treatment Improvement Techniques

The utilisation of multi-modality treatment and greater patient and physician engagement in clinical trials have resulted in progress in the treatment of stomach cancer. Continued participation in relevant studies will lead to future advancements in the treatment of stomach cancer. Several areas of ongoing research are currently being pursued in order to improve the treatment of stomach cancer.

Supportive Care

Treatments meant to prevent and control the side effects of cancer and its treatment are referred to as supportive care. Side effects not only cause discomfort to patients, but they can also prohibit therapy from being delivered at its intended dose and timing. It is critical to properly manage side effects associated with cancer and its therapy in order to obtain optimal treatment outcomes and improve quality of life.